In the video, Dr. Dan goes through the biology and rationale of using chemotherapeutic agents to treat gastroesophageal cancer. Dr. Dan discusses the mechanism of action of commonly used chemotherapies for gastroesophageal cancer, including antimetabolite pyrimidine antagonists (5fluorouracil (5FU) and leucovorin (folinic acid), capecitabine, trifluridine/tipiracil); platinum agents (oxaliplatin, cisplatin, and carboplatin); topoisomerase inhibitors (irinotecan); and taxane mitotic spindle inhibitors (paclitaxel and docetaxel).

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