E1 vs E2 Reactions: Chad breaks down everything the undergraduate organic chemistry student needs to know regarding E1 and E2 reactions including substrate effects, base effects, solvent effects, and what makes a good leaving group. The mechanisms are covered including the antiperiplanar requirement and concerted mechanism of E2 reactions and the multistep mechanism centering on carbocation formation of E1 reactions.

You'll also learn Zaitsev's Rule (Saytzeff's Rule), how to predict the Zaitsev product, and the exceptions to Zaitsev's Rule when the Hofmann product (antiZaitsev product) is the major product under certain conditions for E2 reactions. Finally, Chad concludes the lesson working a few examples so that you clearly understand how to distinguish between E1 and E2 reactions.

Happy Studying!

00:00 Stability of Alkenes
03:21 Zaitsev's Rule in Elimination Reactions
07:02 E2 Reactions
09:50 Antiperiplanar Stereoselectivity of E2 Reactions
25:20 Hofmann Elimination Using Bulky Bases in E2 Reactions
28:54 Hofmann Elimination with Poor Leaving Groups in E2 Reactions
31:53 E1 Reactions
37:12 Distinguishing Between E1 and E2

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