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Video by Dr. Dawn Elise Snipes on integrative behavioral health approaches including counseling techniques and skills for improving mental health and reducing mental illness.

Acetylcholine
Objectives
Review the function of Acetylcholine
Identify mood and behavioral disorders associated with acetylcholine imbalance
Explore interaction between acetylcholine and other neurotransmitters and hormones
Function of Acetylcholine
Stimulating skeletal muscles, smooth muscles dilation of blood vessels, slowed heart rate, increased body secretions
Memory and Learning
Attention
Cognition
Motivation
Arousal
Promoting REM sleep
The central nervous system undergoes several dynamic changes during sleep, which are mediated by norepinephrine, serotonin, and acetylcholine.
Sleep contributes to memory and brain plasticity and triggers overnight learning
Immunity: During infection this immunederived ACh is necessary for the T cells to migrate into infected tissues
Implication in Mood and Behavioral Disorders
Alzheimer’s patients have low acetylcholine levels
Parkinson’s
Delirium: Caused by acetylcholine deficiency and dopamine excess, relative to each other
Anxiety: In excess compared to other NTs, acetylcholine increases anxiety
nAChR agonists
Can improve mood and cognitive performance in depressed individuals
regulate mood, anxiety, and aggression related behavioral states
Symptoms
Excess
Increases hypervigilance
Increases fear learning
Increases anxiety
Increases CB1 receptors promoting eating
Contributes to rumination and reduced psychological flexibility
Can cause delirium, confusion, headache, or drowsiness
Increased body temperature and flushing
Increased blood pressure
Increases the release of gastric acid
Acetylcholine and Mood
Unipolar Depression
AChEI: Worsened depression (induced in controls)
mAChR agonist: Worsened depression (induced in controls w/ cannabis and with Alzheimer’s)
Antimuscarinic: Antidepressant
nAChR agonist: Antidepressant in nonsmokers
Bipolar depression
AChEi: Worsened depression
AChR agonist: Worsened depression
Antimuscarinic: Antidepressant
Bipolar mania
AChEI: Reduced mania
AChR agonist: Reduced mania

Summary
Acetylcholine is not often talked about but is a necessary excitatory neurotransmitter
Acetylcholine interacts with gonadal hormones, thyroid hormones and several neurotransmitters
Acetylcholine is important for energy, memory, attention, regulation of muscle contraction and much more.
Choline is necessary to make acetylcholine
Tyrosine is necessary to make acetylcholine
Too much acetylcholine contributes to anxiety and irritability, too little contributes to anhedonia


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