Alcohol Metabolism And Chronic Alcoholism This is the video on metabolism of alcohol by Alcohol dehydrogenase, Aldehyde Dehydrogenase, MEOS and Catalse, Biochemical changes occuring due to Alcohol, Mechanism of Disulfiram And Chronic Alcoholism with NEET PG MCQs.
Enzymes for the Metabolism of Alcohol 01:07 minutes
Mechanism of Microsomal Ethanol Oxidizing System (MEOS) 03:00 minutes
Alcohol Metabolism 04:35 minutes
Disulfiram 06:26 minutes
Biochemical changes due to alcohol 07:21 minutes
Chronic Alcoholism 10:04 minutes
Laboratory finding in chronic alcoholism 11:53 minutes
NEET PG MCQs 12:37 minutes

Liver is the major site of ethanol oxidation.
At least three enzyme systems are capable of ethanol oxidation
1. Alcohol dehydrogenase (zinc dependent enzyme).
2. Microsomal ethanol oxidizing system (MEOS).
3. Catalase of peroxisomes.

Only 2–10% of ethanol is excreted unoxidized in the urine and lungs.
Protective Mechanism of Microsomal Ethanol Oxidizing System (MEOS)
• Some metabolism of ethanol takes place via a cytochrome P450dependent microsomal ethanol oxidizing system (MEOS) involving NADPH and O2.
• So NADH/NAD+ ratio is not altered hence account for metabolic tolerance in chronic alcoholics.
• This system is inducible hence increases in activity in chronic alcoholism.
• In some Asian populations and Native Americans, alcohol consumption results in increased adverse reactions to acetaldehyde owing to a genetic defect of mitochondrial aldehyde dehydrogenase.
Disulfiram inhibits the ALDH which leads to accumulation of acetaldehyde.

Accumulation of Acetaldehyde causes Headache, Heaviness of the head Flushing, Hypotension, Palpitation, nausea and burred vision.

That’s why its used as treatment for the chronic alcoholism.

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