While testosterone replacement therapy (TRT) has become more popular and has been proven to be an effective treatment for male hypogonadism, it raises several safety concerns. In this episode of the Better Edge podcast, Joshua A. Halpern, MD, assistant professor of Urology at Northwestern Medicine, discusses alternative therapies to TRT, including selective estrogen receptor modulators (SERMs), human chorionic gonadotropin (hCG) and aromatase inhibitors. These therapies can be used to promote the endogenous production of testosterone. Dr. Halpern recently presented a plenary on this topic at the 2022 American Urological Association Annual Meeting.