The body has its own pain relief system that gets activated when experiencing pain.
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As a painful stimulus ascends to the cerebral cortex (to become consciously aware of the pain) it sends signals to multiple other areas of the brain. This includes:
Amygdala (emotion)
Hypothalamus (flight/fight response)
Reticular formation (arousal and consciousness)
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1⃣All of these regions, including the cortex, will send a signal to the
2⃣Magnus Raphe Nucleus (located at the midline of the medulla) and will
3⃣Send a serotonergic signal to the spinal cord
4⃣Stimulate a neuron in the spinal cord that releases Enkaphalin (opioid)
5⃣Enkephalin will bind to opioid receptors (delta opioid receptors) of both the pre and post synaptic pain neuron.
6⃣Stopping the pain signal!!

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