Bilirubin is a metabolic endproduct of heme, a component of hemoglobin. In healthy individuals, approximately 80% of heme is produced during the breakdown of aged erythrocytes in the spleen. The remaining 20% accumulate during red blood cell formation in the bone marrow, also termed erythropoiesis.

Outline:
00:00 Introduction
00:45 Bilirubin metabolism
04:07 Biliary obstruction
04:23 Urine dipstick

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