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Chapter List:
00:00 Intro
00:23 Take home message
02:05 Why Use Antipsychotics for ADHD?
05:38 What are Antipsychotics and ATypical Antipsychotics?
07:47 Usage of Antipsychotics for Mental Health Conditions
12:51 Studies on Antipsychotics for ADHD
15:41 Potential Side Effects of Risperidal and Abilify
19:49 Comparing Risperidal and Abilify Side Effects
24:37 Conclusion

If ADHD was really all about dopamine deficits, and antipsychotics were just dopamine blockers, then the two would make an awful combination. But newer antipsychotics have multiple actions on multiple dopamine receptors, as well as on other neurotransmitters, and different effects on ongoing versus episodic dopamine release.

Although not firstchoice options, two atypical antipsychotics, Abilify (aripiprazole) and Risperdal (risperidone) are being used extensively, in many countries, to treat ADHD. Numerous case control and open trial studies indicate that these medications can be safe and effective. But we lack sizable, randomizedcontrolled studies that show they really work.

Both medications can cause serious side effects, with most metaanalyses suggesting that aripiprazole is substantially less likely to cause problems.

In my clinical practice I have seen several adults with ADHD (and depression) with positive responses to aripiprazole.

References:
HeadtoHead Comparison of Aripiprazole to Risperidone in the Treatment of ADHD Symptoms in Children with Autism Spectrum Disorder and ADHD: A Pilot, OpenLabel, Randomized Contolled Study (2016)
https://link.springer.com/article/10....

Aripiprazole/Methylphenidate Combination in Children and Adolescents with Disruptive Mood Dysregulation Disorder and AttentionDeficit/Hyperactivity Disorder: An OpenLabel Study (2016)
https://pubmed.ncbi.nlm.nih.gov/30148...

Systematic review of clinical trials of aripiprazole for treating attention deficit hyperactivity disorder (2013)
https://pubmed.ncbi.nlm.nih.gov/24141...

Aripiprazole in children with attentiondeficit/hyperactivity disorder (2008)
https://pubmed.ncbi.nlm.nih.gov/18759...

Full Chapter List:
00:00 Intro
00:23 Take home message
02:05 Why Use Antipsychotics for ADHD?
03:53 Risperidone and Aripiprazole (Risperidal / Abilify)
05:38 What are Antipsychotics and ATypical Antipsychotics?
07:47 Usage of Antipsychotics for Mental Health Conditions
08:57 Effects of Risperidone
10:28 Effects of Aripiprazole
12:51 Studies on Antipsychotics for ADHD
15:41 Potential Side Effects of Risperidal and Abilify
17:18 Sedation
17:56 Movement Disorders
19:15 Metabolic Syndrome
19:49 Comparing Risperidal and Abilify Side Effects
23:29 Risperidone Studies on Rats
24:37 Conclusion
26:00 Outro



Psychiatrist, neuroscientist, and author John Kruse, MD, PhD presents practical, actionable, wellresearched information about treatment options that scientists and clinicians recommend for adult ADHD and other mental health conditions. Subscribe if you're curious about how neuroatypical brains can optimize their functioning in our shared, and somewhat strange, world.

Dr. Kruse has posted talks in both the "live" and the "video" sections of this channel. Thumbnails on ADHD topics have a pink background, and those on more general mental health topics have a purple background. A small collection of ADHDTrump videos have an orange background.

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