If you enjoyed this video, you might like my book: https://ageless.link/

I saw a Twitter thread about Bryan Johnson’s ‘Blueprint’, claiming that he’d made himself biologically younger with a highly optimised combination of diet, supplements and exercise. What could that mean? And should we all start chugging 25 pills a day to start on the Blueprint ourselves? Probably not…but the biology behind it is surprisingly interesting.


Chapters

00:00 A tweet goes viral
00:44 Getting ‘biologically younger’
01:23 NAD levels
03:09 Maximum heart rate
04:12 Epigenetic clocks
07:12 Step 1: the Blueprint diet
09:23 Step 2: ALL THE SUPPLEMENTS
11:43 Step 3: track progress
12:40 Conclusion

Sources and further reading

My book, Ageless: The new science of getting older without getting old , goes into far more depth about rapamycin, metformin and epigenetic clocks, and lots more! https://ageless.link/
Max Hertan’s extremely retweeted thread on Twitter:   / 1595213398358171649  
My thread in response:   / 1595398429018312705  
‘Agepredicted maximal heart rate revisited’ https://www.sciencedirect.com/science...
The ‘Horvath clock’ https://genomebiology.biomedcentral.c...
The ‘PhenoAge’ clock https://www.agingus.com/article/1014...
Bryan Johnson’s Project Blueprint website https://blueprint.bryanjohnson.co/

Corrections:
01:26 I say a decrease in NAD levels, when I mean a decrease in ‘biological age’ which Bryan infers from an increase in NAD.
02:00 I say that Bryan takes NMN to increase his NAD levels when actually he uses a slightly different supplement called NR. The logic and issues with this are the same though.
03:08 Same mistake as NAD levels, but with maximum heart rate!
03:52 And again… D’oh! These are, of course, therefore shown as a decrease on the chart… And also, while a higher maximum heart rate is associated with youth, a lower resting heart rate is of course healthier (learn more in my video with Medlife Crisis here:    • The most important number for your he...  ) so perhaps you can see how I got confused while recording!

I’ve corrected all this in the subtitles for the video.

And finally…

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Read my book, Ageless: The new science of getting older without getting old https://ageless.link/