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In this “Ask Me Anything” (AMA) episode, Peter dives deep into the question of whether there is such a thing as “too much exercise.” He explores the theoretical “Jcurve” relationship between exercise and longevity, whereby mortality risk declines with increasing activity levels only to see an uptick above a certain exercise volume threshold. While Peter maintains that exercise is perhaps the single most important tool we have to live longer and live better, he explains the challenges involved in identifying an optimal dose. He takes a hard look at studies—many of which have contradictory results—to highlight major limitations in methodology and how readers could be misled. Additionally, he discusses the rare, but real, risks associated with extreme levels of physical activity and concludes by weighing the benefits against the risks of exercise.

In this sneak peek, we discuss:
00:00 Intro
00:08 How exercise reduces risk for allcause mortality
06:15 Defining the metric called “MET” and how it’s useful for evaluating different exercises

In the full episode, we also discuss:
The challenge in determining the optimal dose of exercise and the limitations of methods used to study the effect of exercise;
Using VO2 max as a proxy for fitness to better predict mortality risk;
Reviewing data which support the theory of a “Jcurve” relationship between exercise and longevity;
Importance of understanding pvalues and statistical significance;
Deconstructing the studies that show a Jcurve: major limitations and how one could be misled;
Peter’s takeaways on the theoretical “Jcurve” relationship between exercise and longevity;
Risk of sudden cardiac death from vigorous physical exertion;
Atrial fibrillation associated with extreme levels of exercise;
Parting thoughts: benefits of exercise far outweigh the risks;
More.


About:

The Peter Attia Drive is a weekly, ultradeepdive podcast focusing on maximizing health, longevity, critical thinking…and a few other things. With over 45 million episodes downloaded, it features topics including fasting, ketosis, Alzheimer’s disease, cancer, mental health, and much more.

Peter is a physician focusing on the applied science of longevity. His practice deals extensively with nutritional interventions, exercise physiology, sleep physiology, emotional and mental health, and pharmacology to increase lifespan (delay the onset of chronic disease), while simultaneously improving healthspan (quality of life).

Learn more: https://peterattiamd.com

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Disclaimer: This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctorpatient relationship is formed. The use of this information and the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions. I take conflicts of interest very seriously. For all of my disclosures and the companies I invest in or advise, please visit my website where I keep an uptodate and active list of such companies.