This is a summary of the CPIC guideline for serotonin reuptake inhibitors and variation in the genes CYP2D6, CYP2C19, CYP2B6, HTR2A and SLC6A4.

This video will focus on the genedrug pairs with no recommendations. Videos covering the genedrug pairs with recommendations in this guideline can be found at the following links:

Citalopram, escitalopram and CYP2C19    • CPIC guideline for citalopram, escita...  
Fluvoxamine and CYP2D6    • CPIC guideline for fluvoxamine and CY...  
Paroxetine and CYP2D6    • CPIC guideline for paroxetine and CYP2D6  
Sertraline and CYP2C19, CYP2B6    • CPIC guideline for sertraline and CYP...  
Venlafaxine and CYP2D6    • CPIC guideline for venlafaxine and CY...  
Vortioxetine and CYP2D6    • CPIC guideline for vortioxetine and C...  

Guideline and supplemental information https://cpicpgx.org/guidelines/cpicg...

Guideline annotation for duloxetine and CYP2D6 https://www.pharmgkb.org/guidelineAnn...

Guideline annotation for fluoxetine and CYP2D6 https://www.pharmgkb.org/guidelineAnn...

Guideline annotation for desvenlafaxine, duloxetine, fluoxetine, fluvoxamine, levomilnacipran, milnacipran, paroxetine, sertraline, venlafaxine, vilazodone, vortioxetine and HTR2A https://preview.pharmgkb.org/guidelin...

Guideline annotation for citalopram, desvenlafaxine, duloxetine, escitalopram, fluoxetine, fluvoxamine, levomilnacipran, milnacipran, paroxetine, sertraline, venlafaxine, vilazodone, vortioxetine and SLC6A4 https://preview.pharmgkb.org/guidelin...