This is a summary of the CPIC guideline for serotonin reuptake inhibitors and variation in the genes CYP2D6, CYP2C19, CYP2B6, HTR2A and SLC6A4.

This video will focus on the recommendations for sertraline. Videos covering the recommendations for other genedrug pairs as well as a video about the genedrug pairs with no recommendation in the guideline can be found at the following links:

Citalopram and escitalopram and CYP2C19    • CPIC guideline for citalopram, escita...  
Fluvoxamine and CYP2D6    • CPIC guideline for fluvoxamine and CY...  
Paroxetine and CYP2D6    • CPIC guideline for paroxetine and CYP2D6  
Venlafaxine and CYP2D6    • CPIC guideline for venlafaxine and CY...  
Vortioxetine and CYP2D6    • CPIC guideline for vortioxetine and C...  
Serotonin reuptake inhibitors and CYP2D6, HTR2A and SLC6A4 (no recommendations)    • CPIC guideline for serotonin reuptake...  

Guideline and supplemental information https://cpicpgx.org/guidelines/cpicg...

Annotated guideline and genotype picker https://www.pharmgkb.org/guidelineAnn...

PharmGKB sertraline pathway https://www.pharmgkb.org/pathway/PA16...

CYP2C19 Gene Information Tables https://www.pharmgkb.org/page/cyp2c19...

CYP2B6 Gene Information Tables https://www.pharmgkb.org/page/cyp2b6R...

PharmVar https://www.pharmvar.org/