CRISPRCas genome surveillance: From basic biology to transformative technology

Air date: Wednesday, March 11, 2015, 3:00:00 PM

Category: WALS Wednesday Afternoon Lectures

Runtime: 01:05:13

Description: Wednesday Afternoon Lecture Series

Margaret Pittman Lecture

Dr. Doudna, who specializes in the study of RNA, will present a brief history of the bacterial RNAguided CRISPR biology from its initial discovery through the elucidation of the CRISPRCas9 enzyme mechanism. Using CRISPRCas "clustered regularly interspaced short palindromic repeats" technology provides the foundation for remarkable developments in modifying, regulating, or marking genomic loci in a wide variety of cells and organisms. These results highlight a new era in which genomic manipulation is no longer a bottleneck to experiments, paving the way to fundamental discoveries in biology with applications in all branches of biotechnology, and strategies for human therapeutics. Dr. Doudna will discuss recent findings regarding the molecular mechanism of Cas9 and its use for targeted cellbased therapies.

About the annual Margaret Pittman Lecture:
This annual lecture honors Dr. Margaret Pittman, NIH’s first female lab chief, who made significant contributions to microbiology and vaccine development, particularly in the areas of pertussis and tetanus, during her long career at the National Institute of Allergy and Infectious Diseases.
For more information go to http://wals.od.nih.gov

Author: Jennifer Doudna, Ph.D., Li Ka Shing Chancellor's Chair in Biomedical Sciences and Professor, Department of Molecular and Cell Biology and Department of Chemistry at the University of California, Berkeley; Investigator, Howard Hughes Medical Institute

Permanent link: http://videocast.nih.gov/launch.asp?1...