DENOSUMAB belongs to a group of medicines called RANK ligand inhibitors used to treat osteoporosis in postmenopausal women and men who have an increased risk of fracture. DENOSUMAB is also used to treat bone loss due to reduced testosterone level caused by surgery, due to the treatment with medicines such as glucocorticoids and in patients with prostate cancer. DENOSUMAB may also be used to reduce the risk of fractures in people with multiple myeloma, giant cell tumour of the bone, and to treat high calcium levels caused due to cancer.

DENOSUMAB contains ‘denosumab’, which works by blocking a receptor in the body that causes bone loss, thereby treats bone loss. DENOSUMAB treats giant cell tumour of bone (GCTB) by blocking certain receptors in the tumour cells, thereby slowing the tumour growth. DENOSUMAB helps treat high calcium levels by decreasing bone breakdown as a breakdown of the bones releases calcium. DENOSUMAB makes the bones stronger and less likely to break.

DENOSUMAB will be administered by a healthcare professional; do not selfadminister. In some cases, you may experience common sideeffects such as bone/joint/muscle pain, arm/leg pain, abdominal discomfort, constipation, and painful/frequent urination. You are advised to talk to your doctor if the side effects persist or worsen.

DENOSUMAB might cause osteonecrosis of the jaw; therefore, maintain good dental hygiene and receive regular dental checkups whilst on treatment with DENOSUMAB. Avoid taking DENOSUMAB if you are pregnant. Consult your doctor before taking DENOSUMAB if you are breastfeeding. DENOSUMAB is not recommended for children below 18 years as safety and effectiveness have not been established. Keep your doctor informed about your health condition and medicines to rule out any interactions.

Uses of DENOSUMAB
Osteoporosis, bone loss, giant cell tumour of the bone, high calcium levels.

Medicinal Benefits
DENOSUMAB belongs to a group of medicines called RANK ligand inhibitors used to treat osteoporosis in postmenopausal women and men who have an increased risk of fracture. DENOSUMAB is also used to treat bone loss due to reduced hormone levels caused by surgery or due to treatment with medicines in patients with prostate cancer. It is also used to treat bone loss occurring due to longterm treatment with glucocorticoids in patients who are at an increased risk of fractures. DENOSUMAB may also be used to reduce the risk of fractures in people with multiple myeloma, giant cell tumours of the bone and to treat high calcium levels caused due to cancer. DENOSUMAB binds to a protein on RANK ligand on osteoclast (cells that cause bone breakdown) and inhibits their formation, functioning and survival. Thereby decreases bone breakdown, increases bone density, and strengthens the bone. DENOSUMAB treats giant cell tumour of bone (GCTB) by blocking certain receptors in the tumour cells, thereby slows the tumour growth. DENOSUMAB helps treat high calcium levels by decreasing bone breakdown as the breakdown of the bones releases calcium. DENOSUMAB makes the bones stronger and less likely to break.

Directions for Use
DENOSUMAB will be administered by a healthcare professional; do not selfadminister.

Storage
Store in a cool and dry place away from sunlight between 2 to 8 degree

Side Effects of DENOSUMAB

Bone/joint/muscle pain
Pain in extremities (arm/leg pain)
Abdominal discomfort
Constipation
Painful/frequent urination
Upper respiratory tract infection
Rash
Eczema
Hair loss

This video contains information about denosumab injection including
1. what is denosumab injection
2. denosumab injection mechanism of action
3. Denosumab side effects
4. Denosumab injection how to give
5. Denosumab injection uses in hindi
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