Not interested in hearing Dee Dee's longwinded story, Dexter gives her a silencing formula to keep her quiet. To his horror, he finds out that the formula he gave her turned her into a giant monster, who is still bent on telling her story. When he realizes that nothing can make her quiet, he decides to become a giant monster himself.

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Past the vaulted doors lives the smartest boy the world has ever seen, Dexter, boy genius! He's constantly creating dazzling, worldsaving inventions in his secret laboratory. His big sister Dee Dee frequently wrecks his experiments. However, he has bigger problems such as his nemesis, Mandark, his brilliant rival at Huber Elementary School. Mom and Dad, of course, have no idea what their little angel is up to.