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Digitalis | Digoxin M O A & Role in Congestive Heart Failure

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The main mechanism of action of digitalis is on the sodiumpotassium ATPase of the myocyte. It reversibly inhibits the ATPase resulting in increased intracellular sodium levels. The buildup of intracellular sodium leads to a shift of sodium extracellularly through another channel in exchange for calcium ions
The principal pharmacodynamic property of digitalis is its ability to increase the force of systolic contraction. All other cardiovascular responses are considered to be secondary to the increase in myocardial contraction
Digoxin binds to and inhibits the sodium/potassiumATPase (sodium pump) within the plasma membrane of cardiac myocytes. This inhibition increases the intracellular sodium content which in turn increases the intracellular calcium content which leads to increased cardiac contractility


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