Ocular discomfort is one of the most common reasons for patients seeking ophthalmic care, with millions of patients diagnosed as dry eye disease. However, a subset of these patients have chronic neuropathic corneal pain (NCP), that are related to diseases and surgeries, as well as systemic conditions and therapies, that may mimic dry eye disease and are thus under diagnosed. While NCP is highly debilitating and poorly understood condition, it is a treatable condition if diagnosed properly, through a combination of nerve regenerating eyedrops, oral and device treatments changing nerve function, amniotic membranes, and life style changes, among others. Early intervention results in more rapid improvement in patients. Drs. Pedram Hamrah, Gabriela Dieckman, and Anat Galor explain the disease, discuss treatment options, and provide several patient testimonials.