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Nacetylcysteine (NAC) has been used in the medical arena for decades as a rescue for paracetamol overdose and as a mucolytic in Cystic Fibrosis, but newer research leans towards possible uses in Psychiatry. Although too early to provide guidelines, Professor Michael Berk takes us through the exciting possible future uses of this precursor to glutathione production. Professor Berk explains some of the more recent trials, where the link to Psychiatric benefit came from and where future research into NAC in mental health needs to head.