Everything you need to know about bupropion is covered comprehensively in our thorough Wellbutrin review, which delves into bupropion sideeffects, MOA, and more).
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This video is a comprehensive Wellbutrin review covering its indications, mechanism of action, everything you need to know about bupropion sideeffects, and more. The FDA approved indications for Wellbutrin (bupropion) include major depressive disorder treatment, seasonal affective disorder medication, smoking cessation aid (marketed as Zyban), and weight loss when combined with naltrexone (Contrave) or dextromethorphan (Aplenzin).

As a norepinephrine and dopamine reuptake inhibitor (NDRI), Wellbutrin's mechanism of action involves inhibiting the reuptake of these neurotransmitters. Common Wellbutrin sideeffects include dry mouth, nausea, headache, insomnia, and tremor. More serious potential bupropion sideeffects are seizure risk, sjs (StevensJohnson syndrome), hypomania/mania, blood pressure elevation, and increased suicidal thoughts/behaviors in youth.

Important Wellbutrin drug interactions to consider include CYP2D6 inhibition affecting codeine, beta blockers, and atomoxetine metabolism. Caution is advised with MAOI combinations due to hypertensive crisis risk from increased catecholamines. Wellbutrin's active metabolites like hydroxybupropion contribute to its therapeutic effects. Overall, this comprehensive Wellbutrin medication review covers key aspects for prescribers.

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#depression #psychopharmacology #adhd

Chapters:
00:00 Psychofarm is a Perfect Place for Shade
00:09 It's not Buproprion
01:23 Indications
03:40 Formulations and History
09:09 Mechanism of Action
14:53 Sideeffects
18:35 Metabolism / Metabolites
19:25 Drug drug Interactions
22:12 Outro