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Gonadotropin-releasing hormone (GnRH) agonists

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This video discusses the mechanism of action of cancer therapies Gonadotropinreleasing hormone (GnRH) agonists.
#science #cancer #medicine

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References
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Yamaoka M, Hara T, Kusaka M. Overcoming Persistent Dependency on Androgen Signaling after Progression to CastrationResistant Prostate Cancer. Clinical Cancer Research. 2010;16(17):4319.
DrudgeCoates L. GnRH blockers: A changing paradigm in the management of prostate cancer2010. 8592
Ma CX, Reinert T, Chmielewska I, Ellis MJ. Mechanisms of aromatase inhibitor resistance. Nature Reviews Cancer. 2015;15:26
Brodie A, Sabnis G. Adaptive Changes Result in Activation of Alternate Signaling Pathways and Acquisition of Resistance to Aromatase Inhibitors. Clinical Cancer Research. 2011;17(13):4208.1.
Pietras RJ, MárquezGarbán DC. MembraneAssociated Estrogen Receptor Signaling Pathways in Human Cancers. Clinical Cancer Research. 2007;13(16):4672.
Makridakis N, Buchanan G, Tilley W, Reichardt J. Androgen metabolic genes in prostate cancer predisposition and progression2005. 2892903 p.
Tripathy D, Bardia A, Sellers WR. Ribociclib (LEE011): Mechanism of Action and Clinical Impact of This Selective CyclinDependent Kinase 4/6 Inhibitor in Various Solid Tumors. Clinical Cancer Research. 2017;23(13):3251.
Xu H, Yu S, Liu Q, Yuan X, Mani S, Pestell RG, et al. Recent advances of highly selective CDK4/6 inhibitors in breast cancer. Journal of Hematology & Oncology. 2017;10(1):97.
Ciruelos E, Pascual T, Arroyo Vozmediano ML, Blanco M, Manso L, Parrilla L, et al. The therapeutic role of fulvestrant in the management of patients with hormone receptorpositive breast cancer. The Breast. 2014;23(3):2018.
Nathan MR, Schmid P. A Review of Fulvestrant in Breast Cancer. Oncology and Therapy. 2017;5(1):1729.
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