https://Leah4sci.com/Grignard'>https://Leah4sci.com/Grignard presents: Grignard reacting with a nitrile to form a ketone, complete reaction and step by step mechanism

Watch Next: Organometallic Reagents and Reactions    • Organometallic Reagents and Reactions...  

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Grignard reagents are my goto for chain elongation reactions in orgo 2. This video takes you through the reaction and mechanism of a grignard attacking a nitrile to form a ketone as well as showing you the steps for hydrolysis of the imine intermediate.
You’ll learn the stepbystep mechanism for breaking each of the bonds between the carbon and nitrogen through a sequence of proton transfers and see how a water molecule attacks the iminium ion intermediate to form a new bond to oxygen.
You’ll also learn a shortcut for predicting the structure of the final product.

↪ Links & Resources Mentioned In This Video ↩
▸Grignard Series + Cheat Sheet https://Leah4sci.com/Grignard'>https://Leah4sci.com/Grignard

▸Polar and Nonpolar Covalent Bonding    • Ionic, Polar Covalent and NonPolar C...  
▸Functional Groups Guide https://Leah4sci.com/functionalgroup...



⏱ In this video:
[0:15] Overview of Reaction
[0:33] Why a Grignard Attacks a Nitrile
[0:50] Mechanism for the Grignard and Nitrile Reaction
[1:47] Formation of Imine Intermediate
[4:08] Ammonia Leaving Group
[5:10] Final Ketone Product
[5:53] Shortcut for Predicting Final Product



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