Welcome to Science With Tal!

In this video, we will cover the logic behind Gproteincoupled receptors (GPCRs) and we will look at a specific example: the Gs & Gi pathway. The Gs & Gi pathways are very important to understand, as they mediate many intracellular cascades in neurons and other types of cells.

This conversation on neurons in the CNS derives from important concepts that are described in two previous full discussions:

1 To watch the first part (Signal propagation in the Neuron), make sure to go to:    • Signal Propagation In The Neuron (Neu...  

2 To watch the second (The Neuromuscular Junction as the model of the chemical synapse) make sure to go to:    • Neuromuscular Junction As The Model F...  

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TIMESTAMPS

0:00 Introduction
0:15 Differences between NMJ & CNS neurons
2:13 GPCR overview
6:09 Gs pathway (AC, cAMP, PKA)
10:36 Word on Gi pathway
11:14 Conclusion

RESOURCES

Here is a list of the resources that I’ve used to produce this video. (Author(s): title resource)

Dale Purves: Neuroscience (6th edition)
Eric Kandel: Principles of neural science (6th edition)
Lodish: Molecular Cell Biology (9th edition)
Niswender, Colleen M, and P Jeffrey Conn: Metabotropic glutamate Receptors: physiology, pharmacology, and disease
Bünemann, M et al: Activation and deactivation kinetics of alpha 2A and alpha 2Cadrenergic receptoractivated G proteinactivated inwardly rectifying K+ channel currents
Howlett, Allyn C et al: CB(1) cannabinoid receptors and their associated proteins
Morris, R G: D.O. Hebb: The Organization of Behavior, Wiley: New York; 1949
Stent, G S: A physiological mechanism fo Hebb’s postulate of learning

To have more information on these resources, you can refer to the conclusion section where a more formal citation is provided.

CREDITS

Writing: Tal Klimenko
Voice: Tal Klimenko
Animations: Tal Klimenko
Drawings: Tal Klimenko
Editing: Tal Klimenko
Introductory jingle: Thierry Du Sablond
Conclusion music: lukrembo sunflower (   • lukrembo  sunflower (royalty free vl...  )