#hemolytic #anemia #anemiatreatment #drnajeeb #pharmacology #hematology

Hemolytic Anemia | Classification | Hematology | Dr Najeeb‍⚕

Like this video? Sign up now on our website at https://www.DrNajeebLectures.com
to access 1000+ Exclusive videos on Basic Medical Sciences & Clinical Medicine. These are premium videos (NOT FROM YOUTUBE). All these videos come with English subtitles & download options. Sign up now! Get Lifetime Access for a onetime payment of $59 ONLY!

Sign up now on our website at https://members.drnajeeblectures.com/...

Why sign up for premium membership? Here's why!
Membership Features for premium website members.

1. More than 1000+ Medical Lectures.
2. Basic Medical Sciences & Clinical Medicine.
3. Mobilefriendly interface with android and iOS apps.
4. English subtitles and new videos every week.
5. Download option for offline video playback.
6. Fanatic customer support and that's 24/7.
7. Fast video playback option to learn faster.
8. Trusted by over 2M+ students in 190 countries.

▬▬▬▬▬▬▬▬▬▬ Contents of this video ▬▬▬▬▬▬▬▬▬▬
00:00:00 Introduction
00:01:18 Production of RBCs
00:03:00 Features of RBCs, cytoskeletal of RBC
00:11:12 Cords of billroth
00:13:46 What happens to RBCs in macrophage
00:22:48 Extravascular hemolysis, production of hemosiderin, bilirubin
00:24:00 Bilirubin Binding Protein, Bilirubin protein complex, transportation towards liver
00:26:16 Unconjugated bilirubin
00:28:12 Conjugated bilirubin
00:29:46 Urobilinogen, stercobilinogen
00:32:02 Secretion of urobilinogen through urine
00:32:37 Recap
00:33:26 Hemolytic Anemia
00:36:17 Erythropoietin
00:43:03 Bone marrow erythroid hyperplasia
00:40:00 Compensated hemolytic disease
00:47:27 Compensated hemolytic Anemia
00:52:26 How do we know there is hemolysis or not?
00:54:08 Jaundice
01:02:07 Acholuric Jaundice
01:05:46 Obstructive Jaundice
01:06:48 Evidence of hemolysis
01:08:46 Haptoglobin
01:13:10 Evidence of accelerated erythropoiesis
01:17:09 Reticulocytosis



Hemolytic anemia is classified as normocytic anemia with an MCV of 80 to 100 fL. It is a form of low hemoglobin due to the destruction of red blood cells, increased hemoglobin catabolism, decreased levels of hemoglobin, and an increase in efforts of bone marrow to regenerate products.

There are many types of hemolytic anemia. The condition can be inherited or acquired. "Inherited" means your parents passed the gene for the condition on to you. "Acquired" means you aren't born with the condition, but you develop it.

Hemolytic anemia can occur due to erythrocyte or extraerythrocyte causes. Specifically:
Extraerythrocytic disorders:
Causes of extraerythrocytic disorders that patients with hemolytic anemia often encounter, including:
Increased activation of the interretinal endothelial system: hypersplenism. Immune abnormalities: neonatal hemolytic anemia due to blood group incompatibility, autoimmune anemia, thrombocytopenic purpura. Mechanical trauma Some drugs cause hemolysis: quinine, quinidine, penicillin, methyldopa, clopidogrel. Poisoning: lead, copper... Infection: pathogenic bacteria can cause hemolysis through the direct action of bacterial toxins (clostridium pefringens, alphabeta hemolytic streptococci, meningococcal disease), caused by bacteria that invade and destroy red blood cells (plasmodium sp...) or by producing antibodies (Epstein Bar, mycoplasma). RBC abnormalities:
Intrinsic defects of red blood cells can cause hemolysis involving abnormalities of cell membranes, cell metabolism, or hemoglobin structure. RBC membrane abnormalities: minkowski chauffard disease (reduced erythrocyte strength, autosomal dominant inheritance), squamous cell disease (beta lipoprotein abnormalities), rhabdomyolysis (dominant inheritance) , paroxysmal nocturnal hemoglobinuria (acquired erythrocytosis). Red blood cell enzyme abnormalities: lack of enzymes for red blood cell metabolism.


Join this channel to get access to perks:
Sign up now on our website at https://members.drnajeeblectures.com/...
   / @doctornajeeb  
Follow us on Facebook :   / drnajeeb  
Follow us on Instagram :   / drnajeeblectures