Heparin and warfarin both are known as anticoagulants or blood thinners. There is a difference between uses and mechanism of action of these anticoagulants. This video will help you to understand the differences between warfarin and heparin.

Heparin is a direct anticoagulant. It belongs to thrombin inhibitors and is a major tool for the treatment of arterial and venous thrombosis of different etiology. Heparin is a mixture of high molecular weight sulfated mucopolysaccharides. It is most often used subcutaneously or intravenously. After oral intake, it is inactive and is not absorbed. Because of its large molecule, the heparin does not cross the placental barrier and is not excreted in breast milk. It is effective and safe for use during pregnancy and lactation.
Heparin is used for treatment and prophylaxis of:
deep vein thrombosis,
pulmonary thromboembolism,
during surgical interventions in risk patients,
acute myocardial infarction,
maintenance treatment following fibrinolytic therapy with streptokinase, etc.
One of the serious side effects of heparin is the development of thrombocytopenia.

Warfarin (4hydroxycoumarins) is an indirect anticoagulant. After oral intake, warfarin is rapidly and completely absorbed from the gastrointestinal tract. Warfarin is metabolized in the liver and has a long plasma halflife, which predisposes to cumulation and development of toxic reactions. The main effect of warfarin is inhibition in blood clotting. It falls into risk category X, which means that the risk of its use considerably exceeds the expected benefit. It ejects with the breast milk and passes through the placental barrier.
When using this preparation during pregnancy a characteristic dysmorphism develops. A number of organs and systems are affected, mainly the central nervous system, the locomotory system, the cardiovascular system, the eyes.

Warfarin is used for treatment and prophylaxis of:
deep vein thrombosis,
pulmonary embolism,
valvular heart disease,
atrial fibrillation, etc.

#heparin #warfarin #anticoagulants #bloodthinners #pharmacyd #pharmacydbyasim

Chapters:
0:00 intro
0:10 Anticoagulants(blood thinners)
0:30 Heparin
1:09 Warfarin
1:44 Heparin vs Warfarin differences

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