Here's a short(ish) introduction video on High Flow Nasal Cannula.
We dive into the mechanisms, clinical effects, set up and evidence behind these devices.

Couple of the trials i talked about:

Frat JP, Thille AW, Mercat A, et al. Highflow oxygen through nasal cannula in acute hypoxemic respiratory failure. N Engl J Med 2015; 372:2185.

Ou X, Hua Y, Liu J, et al. Effect of highflow nasal cannula oxygen therapy in adults with acute hypoxemic respiratory failure: a metaanalysis of randomized controlled trials. CMAJ 2017; 189:E260.