Oxygen is sparse at high altitudes but flying in a plane couldn’t be more comfortable. Where do planes get their oxygen?
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Read More:
Oxygen Use in Aviation
http://www.aopa.org/PilotResources/P...
“...you have to use supplemental oxygen if you fly more than 30 minutes at cabin pressure altitudes of 12,500 feet or higher.”

Outdoor Action Guide to High Altitude: Acclimatization and Illnesses
https://www.princeton.edu/~oa/safety/...
“The major cause of altitude illnesses is going too high too fast. Given time, your body can adapt to the decrease in oxygen molecules at a specific altitude. This process is known as acclimatization and generally takes 13 days at that altitude.”

Development of severe hypoxaemia in chronic obstructive pulmonary disease patients at 2,438 m (8,000 ft) altitude
http://erj.ersjournals.com/content/er...
“Patients with lung disease are more vulnerable to low atmospheric pressure than healthy individuals.”
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