How do Direct Thrombin inhibitors (Dabigatran) Work? These direct thrombin inhibitors are anticoagulants that block clotting factor 2 which prevent the production of fibirin. This causes a decrease in blood clots and ultimately "thins" the blood.

There are 5 main drugs in this class: Dabigatran (Pradaxa), Argatroban, Lepirudin, Desirudin & Bivalirudin. They are all anticoagulants These medications are used to treat and prevent blood clots from forming which may lead to heart attack and stroke patients. Anticoagulant therapy seeks to prevent the development of deep vein thrombosis and pulmonary embolisms.

Time Stamps:
Intro 00:00
Breakdown 00:19
Direct Thrombin Inhibitor Overview 00:28
Mechanism of Action 02:20
When to use 04:20
Dosing & Adjustments 06:49
Clinical pearls & Side effects 08:49
Quick Summary 11:29
Short Quiz 13:30


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Answers:
1.)D
2.)A
3.)B
4.)B

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This pharmacology lecture covers topics such as Anticoagulant drugs. We talk about Dabigatran, Argatroban, Lepirudin Desirudin & Bivalirudin. We discuss how these drugs help block the clotting factor 2 which leads to less fibrin being formed. This causes the lowering of blood clots. Also, we talk about the pathophysiology of the clotting cascade, heart attack and stroke and how anticoagulation therapy is beneficial. We discuss the mechanism of action of these DOAC's and their side effects. Brand name of these medications include: Pradaxa.


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