Organic chemistry does not only use abundant forms of atoms but also rare isotopes such as deuterium the heavy form of hydrogen. Addition of "the D" can completely transform a molecule's reactivity and pharmacokinetic properties. Watch this to find out more about the physical chemistry, biochemistry and organic synthesis associated with Deuterium and more specifically, the discovery route and largescale process behind the second deuterated drug to be approved by the US FDA, deucravacitinib (Sotyktu).

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00:00 Why you should care about D
01:40 Deuterium's discovery and application in medicinal chemistry (deutetrabenazine)
06:44 Psoriasis landscape, key molecules and mechanisms of action
09:08 Deucravacitinib Tyk 2 deep dive and outlook
12:33 Discovery chemistry route overview
14:54 Process chemistry route deep dive

Main paper: Development of a Commercial Process for Deucravacitinib, a Deuterated API for TYK2 Inhibition; https://pubs.acs.org/doi/10.1021/acs....
Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS986165; https://pubs.acs.org/doi/abs/10.1021/...

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No information on this channel is intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of information on Youtube.

Some recommended books on organic synthesis:
Clayden, Greeves, Warren; Organic Chemistry (basic organic chemistry knowledge)
Wyatt, Warren; Organic Synthesis: The Disconnection Approach (excellent introduction to retrosynthesis)
Kurti, Czako; Strategic Applications of Named Reactions in Organic Synthesis (extensive toolkit of functional group reactions and applications thereof with common conditions)
Nicolaou et al; Classics in Total Synthesis 13 (the ultimate total synthesis trilogy)
Nicolaou; Molecules That Changed the World (the world's most important molecules and their impact on everyday life)
Carreira, Kvaerno; Classics in Stereoselective Synthesis (compilation of the groundbreaking methods of stereoselective synthesis and application to synthesis of stereochemically complex structures)

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