Our understanding of polycythemia vera (PV) has been transformed by the delineation of the contribution of JAK2 mutations to its pathogenesis. Nevertheless, definitive guidelines for the treatment of the disorder remain to be established. Dr. Vannucchi discusses his approach to the diagnosis and treatment of PV. (Chapter 11, How I Treat: A Compendium for the Practicing Hematologist, 2nd Edition)

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