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How Long For TRT to Work?

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Southwest Integrative Medicine

In this video we will address the question of how long for TRT to work.  Many of my testosterone replacement therapy patients ask similar questions about how long it is going to take before I start to see the benefits of testosterone injections or topical testosterone.  How long for testosterone therapy results. The answer really depends on a few different things.  I will say right out of the gate that initially it is going to take about three weeks before you notice the benefits.  However you may not get the full benefits for almost three months.  In between that time there's a few different things that you want to make sure are optimized and a few different things that can accelerate the benefits.  That's what most of this article is going to be about. Many people starting testosterone replacement therapy wonder how long for their TRT will start to work.  On average I expect people to feel some improvements in about three weeks.   For some it can take longer three to six months even.  In the case you start feeling better early on you may not get the full benefits until several months down the road.  Firsts let's look at  what symptom improvements  you are expecting to see on TRT or testosterone replacement therapy. The main benefits I expect to see when someone has low testosterone and they start testosterone replacement therapy are energy drive and mood.  Along with this you will also typically see improvements in erectile dysfunction and libido. 
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The benefit that most people notice first is with energy mood and drive.  How long depends on:If your dose is correct, If your estrogen levels are not going up, What's happening with your androgen receptors. 
These three things are important but I also wanted to point out that most of us think a little bit is good so more is even better.  That's not always the case for testosterone replacement therapy.  The reason it is not is tied in with the downstream hormone metabolites of testosterone and other hormones.  If you're on a high dose of testosterone and your levels are really high,  your enzymes will be saturated.  The are enzymes like alpha five reductase and aromatase.  The alpha reductase turns testosterone into dihydrotestosterone (DHT) and the aromatase makes estrogen or estradiol. The more testosterone in your system the more DHT and estradiol.  These can cause some side effects. In the case of estradiol, it can diminish the positive effects of the testosterone.  So if you're getting a lot of estrogen production with the increased testosterone it may negate some of the benefits .  Sometimes you just decrease the dose testosterone and things even out.  Most people know that high estrogen negate some of the benefits of their testosterone replacement therapy.   What they sometimes forget is that, you have to check the levels at different times.  You have to make sure you check it later on (maybe 6 mo) into the treatment.  Once you get the estradiol optimized, you will see more benefits but the high estradiol will delay the time it takes you to see benefits.  That doesn't necessarily mean you have to discount the total time and start back from square one.  it may take an additional 3 weeks after the estradiol is normalized.

posted by aber92