How to Mix CathFlo | Declog a Central Line

Instructions for Administration
Preparation of Solution
Reconstitute Cathflo Activase to a final concentration of 1 mg/mL:

Aseptically withdraw 2.2 mL of Sterile Water for Injection, USP (diluent is not provided). Do not use Bacteriostatic Water for Injection.
Inject the 2.2 mL of Sterile Water for Injection, USP, into the Cathflo Activase vial, directing the diluent stream into the powder. Slight foaming is not unusual; let the vial stand undisturbed to allow large bubbles to dissipate.
Mix by gently swirling until the contents are completely dissolved. Complete dissolution should occur within 3 minutes. DO NOT SHAKE. The reconstituted preparation results in a colorless to pale yellow transparent solution containing 1 mg/mL Cathflo Activase at a pH of approximately 7.3.
Cathflo Activase contains no antibacterial preservatives and should be reconstituted immediately before use. The solution may be used for intracatheter instillation within 8 hours following reconstitution when stored at 36–86°F

No other medication should be added to solutions containing Cathflo Activase.

Instillation of Solution into the Catheter
Inspect the product prior to administration for foreign matter and discoloration.
Withdraw 2 mL of solution from the reconstituted vial.
Instill the appropriate dose of Cathflo Activase into the occluded catheter.
After 30 minutes of dwell time, assess catheter function by attempting to aspirate blood. If the catheter is functional, go to Step 7. If the catheter is not functional, go to Step 5.
After 120 minutes of dwell time, assess catheter function by attempting to aspirate blood and catheter contents. If the catheter is functional, go to Step 7. If the catheter is not functional, go to Step 6.
If catheter function is not restored after one dose of Cathflo Activase, a second dose of equal amount may be instilled. Repeat the procedure beginning with Step 1 under Preparation of Solution
If catheter function has been restored, aspirate 4–5 mL of blood in patients greater than 10 kg or 3 mL in patients less than 10 kg to remove Cathflo Activase and residual clot, and gently irrigate the catheter with 0.9% Sodium Chloride Injection, USP.
Any unused solution should be discarded.



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