Venous thromboembolism, or VTE, is a blood clot that forms in the vein. VTE is highly associated with inherited thrombophilia, and is responsible for more annual deaths than breast cancer, HIV and motor vehicle crashes combined. Inherited thrombophilia is the result of genetic mutations that affect the amount or function of proteins in the coagulation system. Inherited thrombophilia is most often caused by mutations in the FV and FII genes.

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