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Liquid - Liquid Extraction

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Pharma Knowledge

Liquid–liquid extraction (LLE) consists in transferring one (or more) solute(s) contained in a feed solution to another immiscible liquid (solvent). The solvent that is enriched in solute(s) is called extract. The feed solution that is depleted in solute(s) is called raffinate.
Liquid–liquid extraction also known as solvent extraction and partitioning, is a method to separate compounds based on their relative solubilities in two different immiscible liquids, usually water and an organic solvent. It is an extraction of a substance from one liquid into another liquid phase. Liquid–liquid extraction is a basic technique in chemical laboratories, where it is performed using a variety of apparatus, from separatory funnels to countercurrent distribution equipment.[not verified in body] This type of process is commonly performed after a chemical reaction as part of the workup, often including an acidic work up.
Contents :
LiquidLiquid Extraction
Terms: Nernst Distribution law and partition coefficient, Distribution coefficient, Distribution Ratio, Percent extraction or extraction efficiency, Separability factor.
TypesSingle extraction (Batch), Multiple extractions, Countercurrent Distribution
and Continuous.
Factors influencing solvent extraction, Emulsion formation problem in extraction and
ways to minimise.
Applications.
Problems based on distribution coefficient
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