Here's a little historical experiment in DCS World on what the most effective way to shoot down USAAF heavy bombers was by the Luftwaffe in World War 2.

DCS Campaigns:

Horrido: https://www.digitalcombatsimulator.co...
Jagdflieger: https://www.digitalcombatsimulator.co...

0:00 Intro
1:04 The Aircraft
3:19 Rear Attack
4:18 Rockets
5:17 Bombs
6:05 From Below
7:32 Side Attack
9:01 Frontal Attack
11:22 Slice Through
12:52 Ramming