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Making and Testing The ANTI-SPICY Molecule (Capsazepine)

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Chemiolis

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In this video I am making and selftesting the molecule Capsazepine (albeit crude), a molecule that blocks access to the receptor activated by the spicymolecule capsaicin, thus removing its ability to cause you the spicy feeling. There is no known literature on its use on humans, it is used to study the TRPV1 ionchannel (spicy/heat receptor) but only in biology or biochemistry.

For the azepine: https://onlinelibrary.wiley.com/doi/1...
For the isothiocyanate I used a general procedure from: https://scihub.se/https://doi.org/10....
For the final coupling: https://scihub.se/https://doi.org/10...

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Check out @LabCoatz_Science who notified me of this molecule.

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posted by arofunner94