Did you know that MDMAassisted therapy was recently proven to be highly effective for people with severe PTSD? In this video, we will break down MDMA's history and discovery, synthetic approaches from the literature including a kiloscale process route and clinical data from a Phase 3 study investigating MDMA's therapeutic benefit.

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* Note, some slides spell safrole as saffrole

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00:00 MDMA might have valuable therapeutic potential
00:37 Uncontrolled drug use is dangerous!!!
00:53 History and discovery of MDMA
02:26 Organic synthesis and chemical reactions: Safrole, piperonal, GMP synthesis
05:43 PTSD burden of disease and unmet need
07:08 Clinical trial design and results
09:48 Shortterm MDMA safety seems acceptable still, longterm or regular use is discouraged!
10:53 Outlook on potential FDA approval

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No information on this channel is intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of information on Youtube.


Key references:
Fully Validated, MultiKilogram cGMP Synthesis of MDMA (ACS Omega 2022, 7, 900−907)
MDMAassisted therapy for severe PTSD: a randomized, doubleblind, placebocontrolled phase 3 study (Nature Medicine 2021, 27, 1025)
The origin of MDMA (‘Ecstasy’) – separating the facts from the myth (Die Pharmazie 2006, 61, 966)

Some recommended books on organic synthesis:
Clayden, Greeves, Warren; Organic Chemistry (basic organic chemistry knowledge)
Wyatt, Warren; Organic Synthesis: The Disconnection Approach (excellent introduction to retrosynthesis)
Kurti, Czako; Strategic Applications of Named Reactions in Organic Synthesis (extensive toolkit of functional group reactions and applications thereof with common conditions)
Nicolaou; Classics in Total Synthesis 13 (the ultimate total synthesis trilogy)
Nicolaou; Molecules That Changed the World (the world's most important molecules and their impact on everyday life)
Carreira, Kvaerno; Classics in Stereoselective Synthesis (compilation of the groundbreaking methods of stereoselective synthesis and application to synthesis of stereochemically complex structures)