This short Double Take video from the New England Journal of Medicine emphasizes the importance of remaining vigilant in broadening the differential diagnosis when clinical cases evolve atypically. Focusing on a patient whose diagnosis was delayed, the video guides viewers through the sequential clinical events that required additional diagnostic evaluation, culminating in the final diagnosis. This video is based on a Clinical ProblemSolving article published in NEJM (Hard to Swallow, by M.J. Litt et al., https://www.nejm.org/doi/full/10.1056..., in the October 7, 2021, issue), and the companion Interactive Medical Case (https://www.nejm.org/doi/full/10.1056..., in the September 30, 2021, issue).

The New England Journal of Medicine is the world’s leading general medical journal. Continuously published for over 200 years, NEJM publishes peerreviewed research along with interactive clinical content for physicians, educators, and the global medical community at NEJM.org.