Tighten goes on a rampage, demanding to fight Megamind, and threatening to kill Roxanne when she tries to reason with him. With Minion's help, Megamind escapes prison, using holographic disguises to make himself appear as Metro Man, and Minion as Megamind, to frighten Tighten away and rescue Roxanne. However, Megamind's speech patterns give him away, and Tighten attacks Megamind, throwing him into the stratosphere. Dehydrating himself into a cube and landing safely in a fountain, Megamind rehydrates next to Tighten and extracts the DNA from him, removing his powers.

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