Lesson on Methionine Metabolism and the Activated Methyl Cycle. Methionine is a sulfurcontaining essential amino acid, which can be processed within the activated methyl cycle to produce sadenosyl methionine (SAM) and tetrahydrofolate (THF). Methionine can also be metabolized to succinylCoA, which can then be utilized in the tricarboxylic acid (TCA) cycle to generate ATP. Two enzymes in these pathways, one in the activated methyl cycle and the other needed to produce succinylCoA, require vitamin B12 for there utilization.
Hey everyone. In this lesson you will be introduced to Methionine Metabolism and the related Activated Methyl Cycle. We will also discuss the purpose of the activated methyl cycle, the enzymes involved in each pathway, which vitamins are required for enzyme activity, and how methionine is converted into succinyl CoA for energy production.
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JJ
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