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Microscopic polyangiitis (MPA) Pathology Vasculitis USMLE Step 1

Microscopic polyangiitis (MPA) is a disorder that causes blood vessel inflammation (vasculitis), which can lead to organ damage. The kidneys, lungs, nerves, skin, and joints are the most commonly affected areas of the body. MPA is diagnosed in people of all ages, all ethnicities, and both genders. The cause of this disorder is unknown.

Symptoms

The symptoms of MPA depend on which blood vessels are involved and what organs in the body are affected. The most common symptoms of MPA include kidney inflammation, weight loss, skin lesions, nerve damage, and fevers. Other symptoms depending on the area(s) of the body affected may include:
• SkinRash
• Lungscough, breathing problems, spitting up blood
• Gastrointestinalbleeding in the gastrointestinal tract, abdominal pain
• Brain/neurologicaltingling, pain, weakness, loss of sensation, seizures
• Musculoskeletaljoint pain, muscle pain

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