We’ve already learned a lot about electrophilic aromatic substitution (EAS) and benzene, but guess what? There’s even more to learn! In this episode of Crash Course Organic Chemistry we’ll revisit our old friends the FriedelCrafts reactions and learn some of their limitations and look at where substitution happens when there are multiple directing groups on a benzene ring. Plus we’ll introduce some benzylic reactions!

Episode Sources:
Master Organic Chemistry: Reactions on the “Benzylic” Carbon: Bromination And Oxidation
Indigo – Ben Valsler, Chemistry World
Travis, A.S. (2009). Anilines: Historical Background. In PATAI'S Chemistry of Functional Groups, Z. Rappoport (Ed.). https://doi.org/10.1002/9780470682531...
Master Organic Chemistry: EAS Reactions (3) – FriedelCrafts Acylation and FriedelCrafts Alkylation
Solomons, G.T. and Fryhle, C.B. (2011) Organic Chemistry. 10th Edition, John Wiley & Sons, Inc., Hoboken.

Series Sources:
Brown, W. H., Iverson, B. L., Ansyln, E. V., Foote, C., Organic Chemistry; 8th ed.; Cengage Learning, Boston, 2018.
Bruice, P. Y., Organic Chemistry, 7th ed.; Pearson Education, Inc., United States, 2014.
Clayden, J., Greeves, N., Warren., S., Organic Chemistry, 2nd ed.; Oxford University Press, New York, 2012.
Jones Jr., M.; Fleming, S. A., Organic Chemistry, 5th ed.; W. W. Norton & Company, New York, 2014.
Klein., D., Organic Chemistry; 1st ed.; John Wiley & Sons, United States, 2012.
Louden M., Organic Chemistry; 5th ed.; Roberts and Company Publishers, Colorado, 2009.
McMurry, J., Organic Chemistry, 9th ed.; Cengage Learning, Boston, 2016.
Smith, J. G., Organic chemistry; 6th ed.; McGrawHill Education, New York, 2020.
Wade., L. G., Organic Chemistry; 8th ed.; Pearson Education, Inc., United States, 2013.

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