MRCP UK Part 2 | Sample Lecture | CAH (Congenital Adrenal Hyperplasia) + Cholesterol + Amenorrhoea Video Descriptions are given below:

CAH (Congenital Adrenal Hyperplasia) + Causes of Amenorrhoea + H & V

Congenital Adrenal Hyperplasia

Overview
• group of autosomal recessive disorders
• affect adrenal steroid biosynthesis
• in response to resultant low cortisol levels the anterior pituitary secretes high levels of ACTH
• ACTH stimulates the production of adrenal androgens that may virilize a female infant

Cause

• 21 hydroxylase deficiency (90%)
• 11 beta hydroxylase deficiency (5%)
• 17 hydroxylase deficiency (very rare)

Congenital adrenal hyperplasia: features

21 hydroxylase deficiency features
• virilisation of female genitalia
• precocious puberty in males
• 60 70% of patients have a salt losing crisis at 1 3 wks of age


11 beta hydroxylase deficiency features

• virilisation of female genitalia
• precocious puberty in males
• hypertension

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