Because of its location in the midsection of the foot, sandwiched between the long bones of the midfoot (called the metatarsals) and the heel bones, the navicular bone is a common site of fractures, especially among athletes. In the vast majority of cases, these fractures or breaks are stress fractures, overuse injuries caused by repetitive stress on the midfoot area. Runners, jumpers, dancers and other athletes are especially prone to these injuries, but they can occur in other people as well, especially among those who have reduced flexion in their feet which results in additional stress being placed on the arch and midfoot region.

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