Network Medicine: From Cellular Interactions to Human Diseases

Air date: Wednesday, February 06, 2013, 3:00:00 PM

Description: Wednesday Afternoon Lecture Series

Given the functional interdependencies between the molecular components in a human cell, a disease is rarely a consequence of an abnormality in a single gene but reflects the perturbations of the complex intracellular network. The emerging tools of network medicine (a holistic approach for investigating networks of interacting molecular and cellular components) offer a platform to systematically explore not only the molecular complexity of a particular disease but also the molecular relationships between apparently distinct (patho)phenotypes. Advances in this direction are essential for identifying new disease genes, uncovering the biological significance of diseaseassociated mutations identified by genomewide association studies and fullgenome sequencing, and identifying drug targets and biomarkers for complex diseases.

Author: AlbertLaszlo Barabasi, Ph.D., Northeastern University

Runtime: 01:03:17

Permanent link: http://videocast.nih.gov/launch.asp?1...