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Nitroglycerin is administered via several different routes. Each form of this medication should be protected from light.
Intravenous or IV nitroglycerin should be directly infused from a glass bottle using special tubing.
Nitroglycerin that comes as a sublingual tablet or translingual spray should not be swallowed, but instead be allowed to absorb into the oral mucosa. A mild burning sensation may be felt in the mouth, but this is a normal and expected side effect. Both the tablet and spray are used to treat acute chest pain and should be taken at the first indication of chest pain.

The patient can take a maximum of three doses, waiting five minutes between each dose. If the chest pain does not go away after the first dose, the patient should call 911. Since both the tablet and spray have a short shelflife, it’s important to always check the expiration date and replace the drug when necessary.

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