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Antiviral drugs are a class of medication used for treating viral infections. Most antivirals target specific viruses, while a broadspectrum antiviral is effective against a wide range of viruses. Unlike most antibiotics, antiviral drugs do not destroy their target pathogen; instead they inhibit their development. This pharmacology lecture discusses the replication cycle of selected viruses such as influenza, HIV (human immunodeficiency virus), hepatitis B & C, herpes virus, as well as mechanism of action of drugs used in treatment of infections caused by these pathogens. Drugs mentioned include: Antiinfluenza agents: M2 ion channel inhibitors Amantadine, Rimantadine; Endonuclease inhibitor Baloxavir; Neuraminidase inhibitors Oseltamivir, Peramivir, Zanamivir; AntiHIV agents: Entry inhibitors Enfuvirtide, Maraviroc, Ibalizumab; Nucleoside reverse transcriptase inhibitors (NRTIs) Abacavir, Emtricitabine, Lamivudine, Tenofovir, Zidovudine; Nonnucleoside reverse transcriptase inhibitors (NNRTIs) Doravirine, Efavirenz, Etravirine, Nevirapine, Rilpivirine; Integrase inhibitors Dolutegravir, Raltegravir; Protease inhibitors Atazanavir, Darunavir, Fosamprenavir, Ritonavir, Saquinavir, Tipranavir; Antihepatitis B agents: Nucleoside/Nucleotide analogues Entecavir, Lamivudine, Adefovir, Telbivudine, Tenofovir; Antihepatitis C agents: NS3/4A protease inhibitors Boceprevir, Glecaprevir, Grazoprevir, Paritaprevir, Simeprevir, Telaprevir, Voxilaprevir; NS5A inhibitors Daclatasvir, Elbasvir, Ledipasvir, Ombitasvir, Pibrentasvir, Velpatasvir; NS5B polymerase inhibitors Dasabuvir, Sofosbuvir; PEGylated interferons α2a and α2b, Ribavirin; Antiherpes agents: Acyclovir, Ganciclovir, Penciclovir, Valacyclovir, Valganciclovir, Famciclovir.

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References/source of selected illustrations:
https://commons.wikimedia.org/wiki/Fi...
https://commons.wikimedia.org/wiki/Fi...
https://doi.org/10.3389/fimmu.2017.00436

00:00 Intro
00:34 Antiinfluenza drugs
03:41 AntiHIV drugs
08:21 Antihepatitis B drugs
10:34 Antihepatitis C drugs
13:25 Antiherpes drugs