Many years ago, the drug clemastine was proven to have remyelinating effects in animal studies. Recently, a new drug, PIPE307, may represent an advance on clemastine. It is more targeted toward the M1 receptor, believed to mediate remyelinating effects, it has excellent penetration into the central nervous system, and it is highly potent. This video reviews the research done on PIPE307 so far and ongoing trials.

Selected Sources:

Targeting the muscarinic M1 receptor with a selective, brainpenetrant antagonist to promote remyelination in multiple sclerosis: https://pubmed.ncbi.nlm.nih.gov/39083...
Premyelinating Oligodendrocytes in Chronic Lesions of Multiple Sclerosis: https://www.nejm.org/doi/full/10.1056...
Phase I Study Evaluating Safety and Tolerability of Escalating Single and Multiple Doses of of PIPE307 and Food Effect in Healthy Volunteers: https://clinicaltrials.gov/study/NCT0...
Study to Evaluate the Safety and Efficacy of PIPE307 in Subjects With RelapsingRemitting Multiple Sclerosis (VISTA): https://www.clinicaltrials.gov/study/...


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Dr. Brandon Beaber is a boardcertified neurologist with subspecialty training in multiple sclerosis and other immunological diseases of the nervous system. He is a partner in the Southern California Permanente Medical Group and practices in Downey, California (South Los Angeles). He has several publications on MS epidemiology and has participated in clinical trials for MS therapeutics. You can follow him on twitter @Brandon_Beaber where he regularly posts about MS news and research.

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he video material by Dr. Brandon Beaber is general educational material on health conditions and is not intended to be used by viewers to diagnose or treat any individual's medical condition. Specifically, this material is not a substitute for individualized diagnostic and treatment advice by a qualified medical/health practitioner, licensed in your jurisdiction, who has access to the relevant information available from diagnostic testing, medical interviews, and a physical examination. To the extent that Dr. Beaber endorses any lifestyle change, behavioral intervention, or supplements, the viewer should consult with a qualified healthcare professional to determine the safety and efficacy of the intervention in light of their individualized information.