Learn why spleen size is an important health focus for people living with polycythemia vera (PV). Get facts about the role of the spleen, what a normal spleen size looks like, and what happens when the spleen is enlarged. Find out how you can take an active role in your health by understanding how to identify spleenrelated symptoms and working with your care team to have your spleen size checked on a regular basis throughout your PV journey. And for adults with PV who have already taken a medicine called hydroxyurea and it did not work well enough or they could not tolerate it, discover what may be possible with Jakafi® (ruxolitinib).

Register now for information, support, and resources about Jakafi. Visit https://www.Jakafi.com/register.aspx.

Jakafi® (ruxolitinib) is a prescription medicine used to treat adults with PV who have already taken a medicine called hydroxyurea and it did not work well enough or they could not tolerate it.

Selected Safety Information

Jakafi can cause serious side effects including low blood counts and infection. Some people who take Jakafi have developed certain types of non‐melanoma skin cancers. Increases in blood cholesterol levels can also occur. In patients who took another JAK inhibitor to treat rheumatoid arthritis, there was an increased risk of potentially fatal cardiovascular events like heart attack or stroke in patients with risk factors for these events who smoke now or smoked in the past, as well as an increased risk of blood clots in legs or lungs and new (secondary) cancers like lymphoma, especially in patients who smoke now or smoked in the past. The most common side effects of Jakafi for certain types of myelofibrosis and PV include: low platelet or red blood cell counts, bruising, dizziness, headache, and diarrhea. Call your doctor for medical advice about side effects.

To learn more about these and other risks, please read the Important Safety Information at https://www.jakafi.com/.

Please see the Full Prescribing Information at https://www.jakafi.com/pi/pi, which includes a more complete discussion of the risks associated with Jakafi.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1800FDA1088.
You may also report side effects to Incyte Medical Information at 18554633463.

Sponsored by Incyte Corporation. Jakafi is a registered trademark of Incyte.
© 2021, Incyte Corporation. MATJAK03725 01/22