Dr Ettienne Myburgh, Panorama Centre for Surgical Oncology (www.pacso.co.za) explains our current understanding of biology of DCIS and how to guide treatment for patients.
Part of the Cape Town Breast Cancer forum talks Feb 2023


0:47 Introduction
5:03 Why treat DCIS
5:52 Clinical Pathological Predictors
8:26 Van Nuys Prognostic Index
9:22 Nomogram to predict recurrence
9:55 Traditional view of how cancer develops
10:34 New models of understanding about progression to invasive cancer
12:25 Genetic evaluation of DCIS and invasive cancer
15:21 Spesific genetic changes
16:03 Importance of germline testing
17:04 Molecular Testing MammaPrint or OncotypeDx
20:43 Microenvironment
24:15 Clinical decision making in DCIS
26:00 Prospective Analysis of VNPI
28:45 Online Nomogram for DCIS by MSK
29:12 Final Thoughts

Corrections: 25:16 Please note Age in col 1 should be over 60