Prototype 2 (stylized as [PROTOTYPE2]) is a 2012 actionadventure video game developed by Radical Entertainment and published by Activision, and the sequel to 2009's Prototype. First announced at the 2010 Spike VGA Awards,[3] it was released in April 2012 for the PlayStation 3 and Xbox 360, and in July 2012 for Microsoft Windows. In July 2015, the game was rereleased alongside its predecessor as the Prototype Biohazard Bundle for the PlayStation 4 and Xbox One.[4] Separate versions of the two games became available in August 2015.[4] Prototype 2 shifts the focus towards a new protagonist, former U.S. Marine Sergeant James Heller, who seeks revenge on Alex Mercer, the protagonist of the original Prototype, after the death of his family during a new outbreak of the Blacklight virus in Manhattan, which was started by Mercer. Heller is infected with a strain of the virus that allows him to keep his humanity while granting him powers similar to Mercer's, including shapeshifting and consuming people, which he uses in his mission to stop Mercer and the Blacklight outbreak.

Upon release, Prototype 2 received generally positive reviews for the PlayStation 3 and Windows versions, and mixed reviews for the Xbox 360 version. Most critics praised it for its entertaining gameplay and improvements over its predecessor in certain areas, although the game's repetitive nature and the main storyline attracted criticism. While the game was a top seller at the time of release, its dwindling sales eventually resulted in the downsizing of Radical Entertainment.[5] A tiein comic book miniseries, which bridges the gap between the two Prototype games, was published by Dark Horse Comics.